IC-3 RT
Research Compound · Product File
In Vitro Research Compound

IC-3 RT

A single-molecule triple agonist of the GLP-1, GIP, and glucagon receptors — studied for metabolic regulation, appetite signaling, and energy balance in research models.

Certificate of Analysis

Independently 8× tested by a US ISO/IEC 17025 lab.

Latest ISO 17025 Pass
99.92%
Purity
✓ Passed full QC panel
VariantIC-3RT · 30 mg
Lot #2026-999
Labeled30 mg
Actual31.78 mg
TestedJul 14, 2026
Full QC PanelISO/IEC 17025
  • Purity (HPLC)99.92%
  • Net Peptide Content31.78 mg
  • Identity (HPLC-RTM)IC-3RT
  • Heavy Metals (ICP-MS)Not Detected
  • Sterility (PCR)No Growth
  • Endotoxin (USP <85>)0.11 EU/mL
  • Fentanyl ScreenNot Detected
View COA
Issued by ILS Laboratories · COA-2026-66WIG5
Description

Mechanism & research context

IC-3 RT is a single-molecule triple agonist of the GLP-1, GIP, and glucagon receptors, studied for metabolic regulation, appetite signaling, and energy balance in research models.

GLP-1
Glucagon-like peptide-1 receptor
GIP
Glucose-dependent insulinotropic polypeptide receptor
Glucagon
Glucagon receptor
Analytical Verification

The full assay panel, per batch

Each batch of IC-3 RT is tested by a U.S.-based, ISO/IEC 17025-accredited laboratory across the following verification protocols.

Identity Confirmation

Compound-specific chromatographic fingerprinting (HPLC) that matches sample retention time and peak profile against certified reference standards, verifying the sample matches the expected compound.

Purity Analysis (≥99% by HPLC)

High-performance liquid chromatography profiling to confirm purity of 99% or greater.

Sterility Screening

Microbial contamination testing on multiple vials per lot, using a DNA-based microarray platform for rapid detection of a broad panel of contaminants to confirm the absence of microbial growth under validated laboratory methods.

Endotoxin Assessment (USP <85>)

Kinetic chromogenic LAL screening for bacterial endotoxin quantitation, performed on multiple vials per lot as an added contamination control beyond microbial testing. Results are reported in EU/mg with full method documentation on the Certificate of Analysis.

Heavy Metal Analysis (ICP-MS)

Multi-element screening for trace elemental contaminants and residual metals introduced during solid-phase peptide synthesis (including copper, zinc, iron, and lead), performed by ICP-MS in accordance with ICH Q3D elemental impurity guidelines.

Conformity Verification

Confirmation of consistent purity and content across multiple vials per lot, ensuring uniformity and reproducibility throughout each lot.

Fill Weight Confirmation

Net content verification to confirm lot consistency.

Fentanyl Screening

Contamination testing to verify that research compounds and peptides are free of fentanyl.

Batch-specific Certificates of Analysis (COAs) are available, documenting full testing results across all verification protocols for research traceability.
Storage Requirements

Stability Information

Avoid freeze/thaw cycles Protect from light Keep refrigerated
Lyophilized (powder)
−20°C
24+ months
Reconstituted
2–8°C
~30 days
  • Store lyophilized powder vials in the freezer when possible.
  • After reconstitution, refrigerate at 2–8°C and protect from light and heat.
  • Use within a typical research handling window after mixing. Swirl gently — never shake.
  • Use sterile technique during reconstitution. For laboratory research use only.
Research References

Peer-reviewed evidence

Peer-reviewed literature for this triple-hormone-receptor agonist (LY3437943, CAS 2381089-83-2). Each links to its source record.

  1. A triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: from discovery to clinical proof of concept Cell Metabolism · 2022 · Coskun T, et al. · PMID 35985340
  2. A novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a multiple-ascending dose trial The Lancet · 2022 · Urva S, et al. · PMID 36354040
  3. Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial N. Engl. J. Med. · 2023 · Jastreboff AM, et al. · PMID 37366315
  4. Retatrutide for people with type 2 diabetes: a randomised, placebo- and active-controlled, parallel-group phase 2 trial The Lancet · 2023 · Rosenstock J, et al. · PMID 37385280
  5. Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease Nature Medicine · 2024 · Sanyal AJ, et al. · PMID 38858523
  6. Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2 trial Lancet Diab. & Endo. · 2025 · Coskun T, et al. · PMID 40609566

Independent laboratory literature and compound data

Laboratory and preclinical literature on this compound can be found through independent public research databases. This is provided as research context only — not medical advice, and not a claim that any specific paper exists or applies to this product.

Terms & Compliance

Terms of sale