GHK-Cu
Research Compound · Product File
In Vitro Research Compound

GHK-Cu

A naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine complexed with copper) — studied in the context of tissue and wound-repair, anti-inflammatory and antioxidant, and collagen and skin research.

Certificate of Analysis

Independently 8× tested by a US ISO/IEC 17025 lab.

8× Testing ISO 17025 Pass
99.76%
Purity
✓ Passed full QC panel
VariantGHK-Cu · 50 mg
Lot #2025-999
Labeled50 mg
Actual51.37 mg
TestedJul 14, 2026
Full QC PanelISO/IEC 17025
  • Purity (HPLC)99.76%
  • Net Peptide Content51.37 mg
  • Identity (HPLC-RTM)GHK-Cu
  • Heavy Metals (ICP-MS)Not Detected
  • Sterility (PCR)No Growth
  • Endotoxin (USP <85>)0.134 EU/mL
  • Fentanyl ScreenNot Detected
View COA
Issued by ILS Laboratories · COA-2026-953896
8× Testing ISO 17025 Pass
99.75%
Purity
✓ Passed full QC panel
VariantGHK-Cu · 100 mg
Lot #2026-999
Labeled100 mg
Actual105.25 mg
TestedAug 13, 2026
Full QC PanelISO/IEC 17025
  • Purity (HPLC)99.75%
  • Net Peptide Content105.25 mg
  • Identity (HPLC-RTM)GHK-Cu
  • Heavy Metals (ICP-MS)Not Detected
  • Sterility (PCR)No Growth
  • Endotoxin (USP <85>)0.117 EU/mL
  • Fentanyl ScreenNot Detected
View COA
Issued by ILS Laboratories · COA-2026-32BEFX
Description

Overview & research context

GHK-Cu is a naturally occurring copper-binding tripeptide (glycyl-L-histidyl-L-lysine complexed with copper). It has been studied in the scientific literature in the context of tissue and wound-repair research, anti-inflammatory and antioxidant research, and collagen and skin research.

Tissue repair
Wound-healing & skin research
Antioxidant
Anti-inflammatory & antioxidant research
Copper binding
Copper-tripeptide & collagen research
CAS Number89030-95-5
SequenceGly-His-Lys
Code NameCopper Tripeptide-1
SynonymsGlycyl-L-histidyl-L-lysine-copper · Prezatide copper
Analytical Verification

The full assay panel, per batch

Each batch of GHK-Cu is tested by a U.S.-based, ISO/IEC 17025-accredited laboratory across the following verification protocols.

Identity Confirmation

Compound-specific chromatographic fingerprinting (HPLC) that matches sample retention time and peak profile against certified reference standards, verifying the sample matches the expected compound.

Purity Analysis (≥99% by HPLC)

High-performance liquid chromatography profiling to confirm purity of 99% or greater.

Sterility Screening

Microbial contamination testing on multiple vials per lot, using a DNA-based microarray platform for rapid detection of a broad panel of contaminants to confirm the absence of microbial growth under validated laboratory methods.

Endotoxin Assessment (USP <85>)

Kinetic chromogenic LAL screening for bacterial endotoxin quantitation, performed on multiple vials per lot as an added contamination control beyond microbial testing. Results are reported in EU/mg with full method documentation on the Certificate of Analysis.

Heavy Metal Analysis (ICP-MS)

Multi-element screening for trace elemental contaminants and residual metals introduced during solid-phase peptide synthesis (including arsenic, cadmium, lead, mercury, and chromium), performed by ICP-MS in accordance with ICH Q3D elemental impurity guidelines.

Conformity Verification

Confirmation of consistent purity and content across multiple vials per lot, ensuring uniformity and reproducibility throughout each lot.

Fill Weight Confirmation

Net content verification to confirm lot consistency.

Fentanyl Screening

Contamination testing to verify that research compounds and peptides are free of fentanyl.

Batch-specific Certificates of Analysis (COAs) are available, documenting full testing results across all verification protocols for research traceability.
Storage Requirements

Stability Information

Avoid freeze/thaw cycles Protect from light Keep refrigerated
Lyophilized (powder)
−20°C
24+ months
Reconstituted
2–8°C
~30 days
  • Store lyophilized powder vials in the freezer when possible.
  • After reconstitution, refrigerate at 2–8°C and protect from light and heat.
  • Use within a typical research handling window after mixing. Swirl gently — never shake.
  • Use sterile technique during reconstitution. For laboratory research use only.
Research References

Peer-reviewed evidence

Peer-reviewed and preclinical literature relevant to GHK-Cu (copper tripeptide-1). Each links to its source record.

  1. GHK-Cu attenuates cigarette smoke-induced pulmonary emphysema and inflammation by reducing oxidative stress Frontiers in Molecular Biosciences · 2022 · Zhang et al. · PMID 35936787
  2. GHK-Cu rescues cigarette smoking-induced skeletal muscle dysfunction via a SIRT1-dependent pathway J. Cachexia, Sarcopenia and Muscle · 2023 · Deng et al. · PMID 36905132
  3. Photo-crosslinkable hyaluronic acid hydrogel embedded with GHK peptide nanofibers for bioactive wound healing Acta Biomaterialia · 2023 · Lee et al. · PMID 37832839
  4. The GHK-Cu tripeptide complex attenuates lung inflammation and fibrosis in silicosis by targeting peroxiredoxin 6 Redox Biology · 2024 · Bian et al. · PMID 38879894
  5. Food-derived tripeptide-copper self-healing hydrogel for infected wound healing Biomaterials Research · 2025 · Chen et al. · PMID 39902373
  6. Injectable hydroxyapatite microsphere filler loaded with GHK-Cu for anti-inflammatory and antioxidant effects Colloids and Surfaces B: Biointerfaces · 2025 · Hu et al. · PMID 40716276

Independent laboratory literature and compound data

Laboratory and preclinical literature on this compound can be found through independent public research databases. This is provided as research context only — not medical advice, and not a claim that any specific paper exists or applies to this product.

Terms & Compliance

Terms of sale